Automated Integrated Forced Degradation and Drug-Excipient Compatibility Studies
نویسندگان
چکیده
منابع مشابه
Drug-Drug/Drug-Excipient Compatibility Studies on Curcumin using Non-Thermal Methods.
PURPOSE Curcumin is a hydrophobic polyphenol isolated from dried rhizome of turmeric. Clinical usefulness of curcumin in the treatment of cancer is limited due to poor aqueous solubility, hydrolytic degradation, metabolism, and poor oral bioavailability. To overcome these limitations, we proposed to fabricate curcumin-piperine, curcumin-quercetin and curcumin-silibinin loaded polymeric nanoform...
متن کاملDrug-Excipient Interactions: Case Studies and Overview of Drug Degradation Pathways
The objective of the current research article is to provide a comprehensive review of excipients impact on the stability of the drug product and their implications during the product development. Recent developments in the understanding of the degradation pathways further impact methodologies used in the pharmaceutical industry for potential stability assessment. The formation of drug excipient...
متن کاملUsing different experimental designs in drug-excipient compatibility studies during the preformulation development of a stable solid dosage formulation.
Different types of factorial experimental designs can be used in compatibility studies of drug development, where many different factors and their interactions should be evaluated to predict their effects on the degradation of the drug substance under study. All possible main and interaction effects of different potential excipients that can constitute the drug product should be evaluated in or...
متن کاملIdentification, Characterization and Drug-Excipient Compatibility of Diltiazem Hydrochloride by Physico-Chemical Techniques
The enhancement of oral bioavailability of poorly water soluble drugs remains one of the most challenging aspects. Utilization of cyclodextrins attracted the attention of many researchers for the enhancement of the dissolution rate. The complexation of diltiazem hydrochloride with βcyclodextrin (CD) was investigated by phase solubility. Phase solubility study was performed to determine stiochio...
متن کاملNew allergy drug excipient allergy
Background Because of its rarity, drug excipients allergy is often unsuspected by the doctors. Some times the active drug is blamed and discontinued unnecessarily when the real culprit is drug excipients. This was suspected when patients reported exacerbation of urticaria with anti histaminic which are actually used for treating urticaria. After suspecting drug excipient as the cause of allergy.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: JALA: Journal of the Association for Laboratory Automation
سال: 2005
ISSN: 1535-5535
DOI: 10.1016/j.jala.2005.09.005